We’re here to guide you.
At RxFRSH we know having fun is what life’s all about. We believe we can do it in a responsible way. This page is meant to be a resource and guide in whatever way you choose to have fun.
At RxFRSH we know having fun is what life’s all about. We believe we can do it in a responsible way. This page is meant to be a resource and guide in whatever way you choose to have fun.
Understanding the negative effects of drugs means recognizing how they can harm your body, mind, relationships, and future. We love to have fun just as much as anyone else. That’s why we believe in being educated on all of the amazing times you’re having.
Supporting Evidence:
The ketamine study describes lower urinary tract symptoms (LUTS), including dysuria, increased urinary frequency, suprapubic pain, and in severe cases, hematuria. These symptoms often correlate with bladder wall thickening and reduced bladder capacity.
Mechanism:
Ketamine causes direct damage to the urothelium (bladder lining) and induces inflammation, leading to ulcerative cystitis and urinary dysfunction. Chronic irritation and structural changes further compromise urinary health.
Supporting Evidence:
Chronic ketamine use is associated with hydronephrosis, papillary necrosis, and obstructive nephropathy, stemming from long-standing bladder dysfunction. Symptoms of K-Cramps, described as vague abdominal pain, often accompany these urinary and renal issues.
Mechanism:
K-Cramps may result from irritation or inflammation of the gastrointestinal or urological systems due to ketamine metabolites. Bladder dysfunction, in turn, leads to obstructed urine flow and increased pressure on the kidneys, causing renal damage.
Supporting Evidence:
The study reports significant impairments in working memory, episodic memory, and executive function among chronic ketamine users. These deficits often correlate with delusional thinking and dissociative symptoms.
Mechanism:
Ketamine blocks NMDA receptors, critical for synaptic plasticity and cognitive functions, in areas like the prefrontal cortex and hippocampus. Chronic use disrupts these neural pathways, leading to cognitive decline.
Supporting Evidence:
The study describes urothelial inflammation, which contributes to bladder pathologies like cystitis, and mentions the role of oxidative stress in neuronal and systemic damage.
Mechanism:
Ketamine induces inflammation via oxidative stress, immune activation, and tissue irritation from metabolites. This inflammation impacts multiple systems, including the urinary tract, brain, and joints.
Supporting Evidence:
The study demonstrates that ketamine is toxic to chondrocytes, the primary cells responsible for maintaining cartilage health. Chondrocyte viability was significantly reduced in a dose- and time-dependent manner, with higher concentrations and longer exposure leading to apoptosis and necrosis.
Mechanism:
Ketamine induces apoptosis (programmed cell death) and necrosis in chondrocytes, impairing their ability to maintain and repair the extracellular matrix of cartilage. This destruction disrupts cartilage integrity, increasing the risk of joint degeneration and conditions like osteoarthritis.
Supporting Evidence:
Chronic ketamine users exhibit emotional instability, depression, and paranoia, contributing to increased psychological stress. Persistent physical symptoms, including LUTS and K-Cramps, amplify stress and emotional strain.
Mechanism:
Ketamine disrupts neurotransmitter systems by blocking NMDA receptors, altering glutamate and dopamine signaling. Combined with chronic pain (e.g., K-Cramps) and inflammation, these changes heighten emotional dysregulation and stress.
We’ve created KFRSH to combat negative effects like above. KFRSH is designed for individuals seeking to support their cognitive function, mental clarity, and overall recovery after intense or demanding experiences. It’s ideal for those looking to maintain balance, replenish vital nutrients, and promote long-term brain and body wellness. Whether for occasional use or as part of a regular wellness routine, KFRSH offers targeted support to help you feel restored and revitalized.
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